The REOLUT Node is consolidating early experimental, clinical and patient advocacy expertise from London, Cambridge and Manchester to build a UK-wide network that will work together to improve the diagnosis and care of patients with rare Lower Urinary Tract (LUT) disorders. In addition to forming a vibrant community of patients, researchers and clinicians that will train the future healthcare and academic leaders in rare LUT disorder research, this node will accelerate discoveries by:
1. Determining novel genetic causes of rare LUT disorders.
2. Understanding how genes are switched on and off in human LUT cells.
3. Optimising gene transfer into human LUT cells to potentially develop novel treatments.
REOLUT Team
Investigators
Researchers
Glenda Beaman
University of Manchester
Filipa Lopes
University of Manchester
Karen Price
University College London
Project Managers
Gabrielle Parkinson
University of Manchester
Peter Style
Project Manager
REOLUT Collaborators
We maintain close partnerships with a multitude of international collaborators: patient support group partners, clinical urologists, clinical nephrologists, epidemiologists, clinical geneticists, experts in translational gene therapy, lower urinary tract physiologists, and experts in human urothelial cell biology. If you are a UK-based clinician and see patients that have severe lower urinary tract issues with no genetic diagnosis, please contact REOLUT@rd-research.org.uk to find out more about the GenRALT study and how it is collecting genetic samples and creating a registry of affected individuals to increase our understanding of these disorders.
Publications
| wdt_ID | wdt_created_by | wdt_created_at | wdt_last_edited_by | wdt_last_edited_at | Category | Letters/corrections/proceedings, queries | Clinical trials | Disease gene discoveries | Phenotype expansion | Mechanistic studies | Translational studies | Genetic counselling / PPIE | Title | Authors | Citation | First Author | Journal/Book | Publication Year | Create Date | PMCID | NIHMS ID | DOI | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 604 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:15 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:15 AM | Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome | Filipa Lopes | eLife | 2024 | 10.7554/eLife.91828 | ||||||||||||||
| 605 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:16 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:16 AM | When should we offer antenatal sequencing for urinary tract malformations? A systematic review, cohort study and meta-analysis | Sarah Sonner | Prenatal Diagnosis | 2024 | 10.1002/pd.6479 | ||||||||||||||
| 606 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:17 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:17 AM | Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies | Jil Stegmann | NPJ Genomic Medicine | 2024 | 10.1038/s41525-024-00398-9 | ||||||||||||||
| 607 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:17 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:17 AM | Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations | Ioannis Bantounas | Stem Cell Reports | 2024 | 10.1016/j.stemcr.2024.04.011 | ||||||||||||||
| 608 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:18 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:18 AM | Urofacial Syndrome | William Newman | GeneReviews | 2023 | NBK154138 | ||||||||||||||
| 609 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:19 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:19 AM | A targeted gene panel illuminates pathogenesis in young people with unexplained kidney failure | Felicity Beal | Journal of Nephrology | 2024 | 10.1007/s40620-024-01964-1 | ||||||||||||||
| 610 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:20 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:20 AM | Case Report: Prolonged survival in Schinzel–Giedion syndrome featuring megaureter and de novo SETBP1 mutation | Glenda Beaman | Frontiers in Pediatrics | 2025 | 10.3389/fped.2025.1534192 | ||||||||||||||
| 611 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:21 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:21 AM | Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization | Soaad Soboh | Cell Death & Disease | 2024 | 10.1038/s41419-024-07262-9 | ||||||||||||||
| 612 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:21 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:21 AM | Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets | Xiaoguang Xu | Nature Communications | 2024 | 10.1038/s41467-024-46132-y | ||||||||||||||
| 613 | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:22 AM | gabrielle.parkinson@manchester.ac.uk | 29/08/2025 08:22 AM | Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model | Daniyal Jafree | Disease Models & Mechanisms | 2025 | 10.1242/dmm.052024 |