Patients with rare conditions often have multi-system issues and coordination of their care is a significant challenge. Manchester benefits from being home to one of the largest multi-specialty hospital Trusts in the North of England, Manchester University NHS Foundation Trust (MFT). Here, we can offer clinical services that span the entire life course, from foetal health to adulthood. MFT is commissioned to deliver a range of highly specialised medical services, is a leading provider of advanced therapies and a centre of excellence in genomic medicine for rare and inherited conditions. With these credentials and long-standing partnerships with other NHS Trusts and academic institutions, in the north-west region and beyond, Manchester aims to be a central hub for clinical and diagnostic services, for those with rare conditions.